Buch

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Übersicht

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Verlag	:	Springer International Publishing
Buchreihe	:	SpringerBriefs in Molecular Science, Protein Folding and Structure
Sprache	:	Englisch
Erschienen	:	16. 12. 2015
Seiten	:	85
Einband	:	Kartoniert
Höhe	:	235 mm
Breite	:	155 mm
Gewicht	:	174 g
ISBN	:	9783319260860
Sprache	:	Englisch

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Inhaltsverzeichnis

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Introduction.- Historical sketch of the discovery and recognition of the function of chaperonins.- Molecular structure of chaperonins.- Folding by enclosure in the chaperonin cavity.- Evolutionary origins and family relations.- Chaperoning mechanisms: folding helpers, folding protectors or misfolding blockers?.- Sequence variations in proteins affecting chaperonin dependence.- Genetic organization of type I chaperonin genes.- Regulation of type I chaperonin gene expression.- Subcellular localization.- Posttranslational modifications.- Variations in Hsp60 and Hsp10 in humans.- Type I chaperonins are essential for cell viability and mutations cause deficiency phenotypes.- Human diseases caused by genetic mutations in the Hsp60/Hsp10 system.- Molecular investigations of disease mechanisms.- Molecular investigations of disease mechanisms.- Outlook.

Deine Buchhandlung

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