Buch

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Übersicht

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Verlag	:	Springer International Publishing
Buchreihe	:	SpringerBriefs in Molecular Science, SpringerBriefs in Biometals
Sprache	:	Englisch
Erschienen	:	03. 06. 2013
Seiten	:	92
Einband	:	Kartoniert
Höhe	:	235 mm
Breite	:	155 mm
Gewicht	:	166 g
ISBN	:	9783319003023
Sprache	:	Englisch

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Stichworte aus dem enthaltenen Werk

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Stichworte im VLB

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Antibiotic Development, Haem Iron, Heme Iron, Iron Sources Organisms, M. Tuberculosis, Mycobacterial Disease, Siderocalin Enterobactin, Siderophores Iron Transporter, Protein-Ligand Interactions, infectious diseases

Produktinformation

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Iron Acquisition by the Genus Mycobacterium summarizes the early evidence for the necessity of iron in mycobacteria and the discovery of the mycobacterial siderophores mycobactin, carboxymycobactin, and exochelin. The structural characterization of the mycobacterial siderophores is described.  The genes so far identified as essential for iron acquisition and maintenance of an infection by pathogenic mycobacteria are discussed.  The potential role of siderocalin in iron gathering by M. tuberculosis is featured. Because new drugs for M. tuberculosis are needed, this brief also emphasizes the design of antibiotics that interfere with siderophore biosynthesis and the use of siderophore analogs and/or conjugates.

Leseprobe

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Deine Buchhandlung

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