Buch

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Übersicht

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Verlag	:	Springer International Publishing
Buchreihe	:	Handbook of Experimental Pharmacology
Sprache	:	Englisch
Erschienen	:	28. 04. 2024
Seiten	:	304
Einband	:	Kartoniert
Höhe	:	235 mm
Breite	:	155 mm
ISBN	:	9783031315251
Sprache	:	Englisch
Illustrationen	:	X, 304 p. 1 illus.

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Inhaltsverzeichnis

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Part I: Physiological Functions of Endo-lysosomal Cation Channels.- NAADP-Mediated Ca2+ Signalling.- NAADP-Dependent TPC Current.- NAADP-Evoked Ca2+ Signaling: The DUOX2–HN1L/JPT2–Ryanodine Receptor 1 Axis.- TPC Functions in the Immune System.- Lysosomal Ion Channels and Lysosome– 1 Organelle Interactions.- TRPML1 and TFEB, an Intimate Affair.- Lysosomal Potassium Channels.- Part II Structure and Composition of TPC and TRPML Channels.- Structure and Function of Plant and Mammalian TPC Channels.- A Structural Overview of TRPML1 and the TRPML Family.- Endo-Lysosomal Two-Pore Channels and Their Protein Partners.- Part III: Tools and Methods to Characterize Endolysosomal Cation Channels.- Electrophysiological Techniques on the Study of Endolysosomal Ion Channels.- The Plant Vacuole as Heterologous System to Characterize the Functional Properties of TPC Channels.- Expanding the Toolbox: Novel Modulators of Endolysosomal Cation Channels.- Characterization of Endo-Lysosomal Cation Channels Using Calcium Imaging.

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